Quinoline-based ATP synthase inhibitors with selective activity against multidrug resistant Acinetobacter baumannii and Pseudomonas aeruginosa
Published: 30 April 2025 | Version 1 | ADP-21-0014 | DOI: https://doi.org/10.71937/KHJT-MX91
Contributors: Katie T. Ward [UNC Asheville] | Alexander P.L. Williams [UNC Asheville] | Angelina L. Dennison [UNC Asheville] | Lena Aamir [UNC Asheville] | Darien L. Allen [UNC Asheville] | Britza Chavez-Arellano [UNC Asheville] | Toni A. Marchlewski [UNC Asheville] | Mars L. Zappia [UNC Asheville] | Amanda L. Wolfe [UNC Asheville] ORCID: 0000-0003-1867-6861 | Phillip Ryan Steed [UNC Asheville] ORCID: 0000-0001-5445-0080
Sponsor: National Institutes of Health | Award No: 1R15AI163474-01 | 1 July 2021 – 30 June 2024
Description This dataset contains biochemical assay data associated with an effort to develop inhibitors of the ATP synthase enzymes of Acinetobacter baumannii and Pseudomonas aeruginosa, which are problematic bacterial pathogens. Quinoline compounds synthesized by the authors were tested for their ability to inhibit bacterial growth, in vitro ATP synthesis activity, and in vitro respiratory activity. Processed results from those assays, as well as a readme file describing each data file, are contained within.
Key Words: Pseudomonas aeruginosa, Acinetobacter baumannii, antibiotics, ATP synthase, enzyme inhibitors
Discipline(s): Biochemstry, Chemistry
Files:
- AB ATP synthesis inhibition data.csv | see Terms of Use note 1
- PA ATP synthesis inhibition data.csv | Tabular Data | see Terms of Use note 1
- AB ETC inhibition data.csv | see Terms of Use note 1
- PA ETC inhibition data.csv | see Terms of Use note 1
- ETC Inhibition IC50 Data.csv | see Terms of Use note 1
- Dataset Readme.pdf | see Terms and Use note 1
- Research Data Transmittal Form | Meta Data | see Terms of Use note 1
Previous Versions: None
Terms of Use
- Copyright 2025 UNC Asheville. This transmittal form is licensed under UNC Asheville’s Open Access Data Use Agreement: <link>https://rda.unca.edu/agreement/</link>.